摘要 目的： 观察血清N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活性对临床上几种肝病诊断的价值。方法： 对103例肝病患者进行血清NAG活性和血清总胆汁酸(TBA)水平测定，并与传统肝功能试验做比较；选取130例健康体检者做血清NAG活性参考值统计。所有项目均采用日立7150型自动生化分析仪测定。结果： 健康人血清NAG测值呈正偏态分布，以P95作参考值上限为21.5U/L。血清NAG在肝癌和酒精性肝病中阳性率分别为80.0%和70.0%，TBA在肝硬变和急性肝炎中阳性率分别为91.6%和68.8%。结论: 血清NAG活性测定不仅对临床各种肝病的诊断有价值，而且其与血清TBA同时检测能更有效地对急性酒精中毒和肝硬变进行早期鉴别诊断。
APPLICATION OF SERUMN-ACETYL-β -D-GLUCOSAMINIDASE
DETERMINATION IN DIAGNOSIS OF LIVER DISEASES
Jia Li,Qiao Wentao
(Department of ClinicalLaboratory;Tianjin Gongan Hospital)
Abstract Objective: Toobserve the value of activity of serum N-acetyl-β-D-glucosaminidase(NAG)in the clinical diagnosis of several liver diseases.Methods: We determinedactivity of serum NAG and level of serum total bile acid(TBA) in 103 patients with liverdiseases,and the results were compared with traditional liver function tests.We alsodetermined activity of serum NAG in 130 healthy individuals,and the results were used asreference values.All the tests were carried on by using HITACHI 7150 biochemicalautoanalyzer.Results: The value of serum NAG in healthy individuals ispositive skewness distribution with the upper threshold of reference value of P 95=21.5 U/L.The positive rate of NAG is 80.0% in liver cancer and 70.0% in alcoholic liverdisease.The positive rate of TBA is 91.6% in cirrhosis and 68.8% in acute hepatitis.Conclusion: Thedetermination of serum NAG is not only valuable for several liver diseases but alsoefficient and earlier for modifying acute alcoholism and cirrhosis when determined withserum TBA together.
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